null

SMILES: COc1ccc2nc(NC(=O)c3cccc4CCN(Cc34)c3ccc(-c4cnn(Cc5ccccc5)c4)c(n3)C(O)=O)sc2c1

InChI Key: InChIKey=NPQULOMUJADAKF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 209065   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM209065 (US9266877, 11) Show SMILES COc1ccc2nc(NC(=O)c3cccc4CCN(Cc34)c3ccc(-c4cnn(Cc5ccccc5)c4)c(n3)C(O)=O)sc2c1 Show InChI InChI=1S/C34H28N6O4S/c1-44-24-10-12-28-29(16-24)45-34(36-28)38-32(41)26-9-5-8-22-14-15-39(20-27(22)26)30-13-11-25(31(37-30)33(42)43)23-17-35-40(19-23)18-21-6-3-2-4-7-21/h2-13,16-17,19H,14-15,18,20H2,1H3,(H,42,43)(H,36,38,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	180	-9.19	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC. US Patent					Assay Description The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Mus musculus (Mouse))	BDBM209065 (US9266877, 11) Show SMILES COc1ccc2nc(NC(=O)c3cccc4CCN(Cc34)c3ccc(-c4cnn(Cc5ccccc5)c4)c(n3)C(O)=O)sc2c1 Show InChI InChI=1S/C34H28N6O4S/c1-44-24-10-12-28-29(16-24)45-34(36-28)38-32(41)26-9-5-8-22-14-15-39(20-27(22)26)30-13-11-25(31(37-30)33(42)43)23-17-35-40(19-23)18-21-6-3-2-4-7-21/h2-13,16-17,19H,14-15,18,20H2,1H3,(H,42,43)(H,36,38,41)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair