null

SMILES: CN(C)CCOc1cccc(Cn2cc(cn2)-c2ccc(nc2C(O)=O)N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)c1

InChI Key: InChIKey=ZQODOCMKSVFZBR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 209072   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM209072 (US9266877, 18) Show SMILES CN(C)CCOc1cccc(Cn2cc(cn2)-c2ccc(nc2C(O)=O)N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)c1 Show InChI InChI=1S/C37H35N7O4S/c1-42(2)17-18-48-27-9-5-7-24(19-27)21-44-22-26(20-38-44)28-13-14-33(40-34(28)36(46)47)43-16-15-25-8-6-10-29(30(25)23-43)35(45)41-37-39-31-11-3-4-12-32(31)49-37/h3-14,19-20,22H,15-18,21,23H2,1-2H3,(H,46,47)(H,39,41,45)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	38	-10.1	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC. US Patent					Assay Description The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Mus musculus (Mouse))	BDBM209072 (US9266877, 18) Show SMILES CN(C)CCOc1cccc(Cn2cc(cn2)-c2ccc(nc2C(O)=O)N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)c1 Show InChI InChI=1S/C37H35N7O4S/c1-42(2)17-18-48-27-9-5-7-24(19-27)21-44-22-26(20-38-44)28-13-14-33(40-34(28)36(46)47)43-16-15-25-8-6-10-29(30(25)23-43)35(45)41-37-39-31-11-3-4-12-32(31)49-37/h3-14,19-20,22H,15-18,21,23H2,1-2H3,(H,46,47)(H,39,41,45)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	621	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair