Found 2 hits for monomerid = 209087 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM209087
(US9266877, 33)Show SMILES CCOC(=O)c1nn(Cc2ccccc2)c(C)c1-c1ccc(nc1C(O)=O)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 |(8.34,5.75,;6.83,5.43,;6.35,3.96,;4.85,3.64,;4.37,2.18,;3.82,4.79,;4.14,6.29,;2.8,7.06,;2.64,8.59,;3.89,9.5,;3.73,11.03,;4.97,11.94,;6.38,11.31,;6.54,9.78,;5.3,8.87,;1.66,6.03,;.33,6.8,;2.29,4.62,;1.52,3.29,;2.29,1.96,;1.52,.62,;-.02,.62,;-.79,1.96,;-.02,3.29,;-.79,4.62,;-.02,5.96,;-2.33,4.62,;-.79,-.71,;-2.33,-.71,;-3.1,-2.04,;-2.33,-3.38,;-3.1,-4.71,;-2.33,-6.05,;-.79,-6.05,;-.02,-4.71,;1.52,-4.71,;2.29,-3.38,;2.29,-6.05,;3.83,-6.05,;4.73,-4.8,;6.2,-5.28,;7.53,-4.51,;8.86,-5.28,;8.86,-6.82,;7.53,-7.59,;6.2,-6.82,;4.73,-7.29,;-.79,-3.38,;-.02,-2.04,)| Show InChI InChI=1S/C37H32N6O5S/c1-3-48-36(47)33-31(22(2)43(41-33)20-23-10-5-4-6-11-23)26-16-17-30(39-32(26)35(45)46)42-19-18-24-12-9-13-25(27(24)21-42)34(44)40-37-38-28-14-7-8-15-29(28)49-37/h4-17H,3,18-21H2,1-2H3,(H,45,46)(H,38,40,44) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| 169 | -9.23 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
ABBVIE INC.
US Patent
| Assay Description
The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc... |
US Patent US9266877 (2016)
BindingDB Entry DOI: 10.7270/Q2H41Q7V |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Mus musculus (Mouse)) | BDBM209087
(US9266877, 33)Show SMILES CCOC(=O)c1nn(Cc2ccccc2)c(C)c1-c1ccc(nc1C(O)=O)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 |(8.34,5.75,;6.83,5.43,;6.35,3.96,;4.85,3.64,;4.37,2.18,;3.82,4.79,;4.14,6.29,;2.8,7.06,;2.64,8.59,;3.89,9.5,;3.73,11.03,;4.97,11.94,;6.38,11.31,;6.54,9.78,;5.3,8.87,;1.66,6.03,;.33,6.8,;2.29,4.62,;1.52,3.29,;2.29,1.96,;1.52,.62,;-.02,.62,;-.79,1.96,;-.02,3.29,;-.79,4.62,;-.02,5.96,;-2.33,4.62,;-.79,-.71,;-2.33,-.71,;-3.1,-2.04,;-2.33,-3.38,;-3.1,-4.71,;-2.33,-6.05,;-.79,-6.05,;-.02,-4.71,;1.52,-4.71,;2.29,-3.38,;2.29,-6.05,;3.83,-6.05,;4.73,-4.8,;6.2,-5.28,;7.53,-4.51,;8.86,-5.28,;8.86,-6.82,;7.53,-7.59,;6.2,-6.82,;4.73,-7.29,;-.79,-3.38,;-.02,-2.04,)| Show InChI InChI=1S/C37H32N6O5S/c1-3-48-36(47)33-31(22(2)43(41-33)20-23-10-5-4-6-11-23)26-16-17-30(39-32(26)35(45)46)42-19-18-24-12-9-13-25(27(24)21-42)34(44)40-37-38-28-14-7-8-15-29(28)49-37/h4-17H,3,18-21H2,1-2H3,(H,45,46)(H,38,40,44) | PDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
ABBVIE INC.
US Patent
| Assay Description
The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models... |
US Patent US9266877 (2016)
BindingDB Entry DOI: 10.7270/Q2H41Q7V |
More data for this
Ligand-Target Pair | |
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