null
SMILES: CN(C)CCCNc1ccc(Cn2cc(cn2)-c2ccc(nc2C(O)=O)N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)cc1[N+]([O-])=O
InChI Key: InChIKey=SWGHOHOEWIDJCI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM209098 (US9266877, 44) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 17 | -10.6 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
ABBVIE INC. US Patent | Assay Description The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc... | US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-like protein 1 (Mus musculus (Mouse)) | BDBM209098 (US9266877, 44) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
ABBVIE INC. US Patent | Assay Description The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models... | US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V | |||||||||||
More data for this Ligand-Target Pair |