null

SMILES: OC(=O)c1nc(ccc1-c1cnn(Cc2ccccc2OCCN2CCOCC2)c1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1

InChI Key: InChIKey=HTSMAYIADJQPMN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 209100   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM209100 (US9266877, 46) Show SMILES OC(=O)c1nc(ccc1-c1cnn(Cc2ccccc2OCCN2CCOCC2)c1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C39H37N7O5S/c47-37(43-39-41-32-9-2-4-11-34(32)52-39)30-8-5-7-26-14-15-45(25-31(26)30)35-13-12-29(36(42-35)38(48)49)28-22-40-46(24-28)23-27-6-1-3-10-33(27)51-21-18-44-16-19-50-20-17-44/h1-13,22,24H,14-21,23,25H2,(H,48,49)(H,41,43,47)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9	-11.0	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC. US Patent					Assay Description The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Mus musculus (Mouse))	BDBM209100 (US9266877, 46) Show SMILES OC(=O)c1nc(ccc1-c1cnn(Cc2ccccc2OCCN2CCOCC2)c1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C39H37N7O5S/c47-37(43-39-41-32-9-2-4-11-34(32)52-39)30-8-5-7-26-14-15-45(25-31(26)30)35-13-12-29(36(42-35)38(48)49)28-22-40-46(24-28)23-27-6-1-3-10-33(27)51-21-18-44-16-19-50-20-17-44/h1-13,22,24H,14-21,23,25H2,(H,48,49)(H,41,43,47)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair