null

SMILES: CN(C)CC#Cc1ccccc1Cn1cc(cn1)-c1ccc(nc1C(O)=O)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1

InChI Key: InChIKey=AAIUEXXGSDEMNM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 209105   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM209105 (US9266877, 51) Show SMILES CN(C)CC#Cc1ccccc1Cn1cc(cn1)-c1ccc(nc1C(O)=O)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C38H33N7O3S/c1-43(2)19-8-12-25-9-3-4-10-27(25)22-45-23-28(21-39-45)29-16-17-34(41-35(29)37(47)48)44-20-18-26-11-7-13-30(31(26)24-44)36(46)42-38-40-32-14-5-6-15-33(32)49-38/h3-7,9-11,13-17,21,23H,18-20,22,24H2,1-2H3,(H,47,48)(H,40,42,46)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	122	-9.43	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC. US Patent					Assay Description The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Mus musculus (Mouse))	BDBM209105 (US9266877, 51) Show SMILES CN(C)CC#Cc1ccccc1Cn1cc(cn1)-c1ccc(nc1C(O)=O)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C38H33N7O3S/c1-43(2)19-8-12-25-9-3-4-10-27(25)22-45-23-28(21-39-45)29-16-17-34(41-35(29)37(47)48)44-20-18-26-11-7-13-30(31(26)24-44)36(46)42-38-40-32-14-5-6-15-33(32)49-38/h3-7,9-11,13-17,21,23H,18-20,22,24H2,1-2H3,(H,47,48)(H,40,42,46)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair