null

SMILES: OC(=O)c1nc(ccc1-c1cnn(Cc2cc(F)cc(F)c2)c1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1

InChI Key: InChIKey=XDCXMFFOTDHZLV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 209107   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM209107 (US9266877, 53) Show SMILES OC(=O)c1nc(ccc1-c1cnn(Cc2cc(F)cc(F)c2)c1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C33H24F2N6O3S/c34-22-12-19(13-23(35)14-22)16-41-17-21(15-36-41)24-8-9-29(38-30(24)32(43)44)40-11-10-20-4-3-5-25(26(20)18-40)31(42)39-33-37-27-6-1-2-7-28(27)45-33/h1-9,12-15,17H,10-11,16,18H2,(H,43,44)(H,37,39,42)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14	-10.7	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC. US Patent					Assay Description The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Mus musculus (Mouse))	BDBM209107 (US9266877, 53) Show SMILES OC(=O)c1nc(ccc1-c1cnn(Cc2cc(F)cc(F)c2)c1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C33H24F2N6O3S/c34-22-12-19(13-23(35)14-22)16-41-17-21(15-36-41)24-8-9-29(38-30(24)32(43)44)40-11-10-20-4-3-5-25(26(20)18-40)31(42)39-33-37-27-6-1-2-7-28(27)45-33/h1-9,12-15,17H,10-11,16,18H2,(H,43,44)(H,37,39,42)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	387	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair