null

SMILES: OC(=O)c1nc(ccc1-c1cnn(Cc2cccc(c2)-c2ccccc2)c1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1

InChI Key: InChIKey=TVRPYMRYYVUXHU-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 209112   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM209112 (US9266877, 58) Show SMILES OC(=O)c1nc(ccc1-c1cnn(Cc2cccc(c2)-c2ccccc2)c1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C39H30N6O3S/c46-37(43-39-41-33-14-4-5-15-34(33)49-39)31-13-7-11-27-18-19-44(24-32(27)31)35-17-16-30(36(42-35)38(47)48)29-21-40-45(23-29)22-25-8-6-12-28(20-25)26-9-2-1-3-10-26/h1-17,20-21,23H,18-19,22,24H2,(H,47,48)(H,41,43,46)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	174	-9.21	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC. US Patent					Assay Description The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Mus musculus (Mouse))	BDBM209112 (US9266877, 58) Show SMILES OC(=O)c1nc(ccc1-c1cnn(Cc2cccc(c2)-c2ccccc2)c1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C39H30N6O3S/c46-37(43-39-41-33-14-4-5-15-34(33)49-39)31-13-7-11-27-18-19-44(24-32(27)31)35-17-16-30(36(42-35)38(47)48)29-21-40-45(23-29)22-25-8-6-12-28(20-25)26-9-2-1-3-10-26/h1-17,20-21,23H,18-19,22,24H2,(H,47,48)(H,41,43,46)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair