BDBM20969 2-Aryloxy-4-alkylaminopyridine, 5a::methyl 2-(4-chloro-2,6-dimethylphenoxy)-4-{[(2S)-1-hydroxybutan-2-yl]amino}-6-methylpyridine-3-carboxylate

SMILES: CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)OC

InChI Key: InChIKey=IWNVXQFPEPXFQP-HNNXBMFYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20969   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor (Rattus norvegicus (rat))	BDBM20969 (2-Aryloxy-4-alkylaminopyridine, 5a | methyl 2-(4-c...) Show SMILES CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)OC |r| Show InChI InChI=1S/C20H25ClN2O4/c1-6-15(10-24)23-16-9-13(4)22-19(17(16)20(25)26-5)27-18-11(2)7-14(21)8-12(18)3/h7-9,15,24H,6,10H2,1-5H3,(H,22,23)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.40	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7
					More data for this Ligand-Target Pair