BDBM209899 US9273014, 28

SMILES: Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12

InChI Key: InChIKey=AHQDKFUMSUHJRJ-WJONJSRFSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 209899   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Notch 3 intracellular domain (Notch 3) (Homo sapiens (Human))	BDBM209899 (US9273014, 28) Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:8| Show InChI InChI=1S/C26H25ClF6N4O3/c1-13-4-2-5-14(12-13)19-17-6-3-7-18(27)20(17)36-24(40)22(35-19)37-23(39)16(9-11-26(31,32)33)15(21(34)38)8-10-25(28,29)30/h2-7,12,15-16,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t15-,16+,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.				US Patent US9273014 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DVX
					More data for this Ligand-Target Pair
Notch 1 intracellular domain (Notch 1) (Homo sapiens (Human))	BDBM209899 (US9273014, 28) Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12 |r,t:8| Show InChI InChI=1S/C26H25ClF6N4O3/c1-13-4-2-5-14(12-13)19-17-6-3-7-18(27)20(17)36-24(40)22(35-19)37-23(39)16(9-11-26(31,32)33)15(21(34)38)8-10-25(28,29)30/h2-7,12,15-16,22H,8-11H2,1H3,(H2,34,38)(H,36,40)(H,37,39)/t15-,16+,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.				US Patent US9273014 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DVX
					More data for this Ligand-Target Pair