BDBM209901 US9273014, 30::US9273014, 35

SMILES: NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O

InChI Key: InChIKey=KWECVZITGSUXJY-GSHUGGBRSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 209901   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Notch 1 intracellular domain (Notch 1) (Homo sapiens (Human))	BDBM209901 (US9273014, 30 | US9273014, 35) Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O |r,t:21| Show InChI InChI=1S/C26H26F6N4O4/c27-25(28,29)11-9-16(21(33)38)17(10-12-26(30,31)32)23(39)36-22-24(40)34-19-4-2-1-3-18(19)20(35-22)15-7-5-14(13-37)6-8-15/h1-8,16-17,22,37H,9-13H2,(H2,33,38)(H,34,40)(H,36,39)/t16-,17+,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.				US Patent US9273014 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DVX
					More data for this Ligand-Target Pair
Notch 3 intracellular domain (Notch 3) (Homo sapiens (Human))	BDBM209901 (US9273014, 30 | US9273014, 35) Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O |r,t:21| Show InChI InChI=1S/C26H26F6N4O4/c27-25(28,29)11-9-16(21(33)38)17(10-12-26(30,31)32)23(39)36-22-24(40)34-19-4-2-1-3-18(19)20(35-22)15-7-5-14(13-37)6-8-15/h1-8,16-17,22,37H,9-13H2,(H2,33,38)(H,34,40)(H,36,39)/t16-,17+,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.				US Patent US9273014 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DVX
					More data for this Ligand-Target Pair
Notch 3 intracellular domain (Notch 3) (Homo sapiens (Human))	BDBM209901 (US9273014, 30 | US9273014, 35) Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O |r,t:21| Show InChI InChI=1S/C26H26F6N4O4/c27-25(28,29)11-9-16(21(33)38)17(10-12-26(30,31)32)23(39)36-22-24(40)34-19-4-2-1-3-18(19)20(35-22)15-7-5-14(13-37)6-8-15/h1-8,16-17,22,37H,9-13H2,(H2,33,38)(H,34,40)(H,36,39)/t16-,17+,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.				US Patent US9273014 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DVX
					More data for this Ligand-Target Pair
Notch 1 intracellular domain (Notch 1) (Homo sapiens (Human))	BDBM209901 (US9273014, 30 | US9273014, 35) Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O |r,t:21| Show InChI InChI=1S/C26H26F6N4O4/c27-25(28,29)11-9-16(21(33)38)17(10-12-26(30,31)32)23(39)36-22-24(40)34-19-4-2-1-3-18(19)20(35-22)15-7-5-14(13-37)6-8-15/h1-8,16-17,22,37H,9-13H2,(H2,33,38)(H,34,40)(H,36,39)/t16-,17+,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.				US Patent US9273014 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DVX
					More data for this Ligand-Target Pair