BDBM210747 US9290454, 1.2
SMILES: C[C@@H](NC(=O)c1ccc2c(c1)cc(CCCCC(O)=O)n(Cc1ccc(F)cc1)c2=O)c1ccc(F)cc1
InChI Key: InChIKey=HUEONONVVDTHFC-LJQANCHMSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM210747 (US9290454, 1.2) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Curated by ChEMBL | Assay Description Antagonist activity at human CRTh2 expressed in HEK cells assessed as inhibition of DK-PGD2-mediated attenuation of forskolin-induced cAMP accumulati... | Bioorg Med Chem Lett 27: 5344-5348 (2017) Article DOI: 10.1016/j.bmcl.2017.07.064 BindingDB Entry DOI: 10.7270/Q2HX1G7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM210747 (US9290454, 1.2) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 49.0 | -10.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 50 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Radioligand binding was performed using filtration or scintillation proximity assay (SPA) technology. SPA assays were done at room temperature in 10 ... | US Patent US9290454 (2016) BindingDB Entry DOI: 10.7270/Q2W66JMQ | |||||||||||
More data for this Ligand-Target Pair |