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SMILES: CCC(=O)O[C@@H]1CCC(C[C@H]1C)C(C)(O)c1ncc(s1)-c1cc(C)cc(Nc2nccc(C)n2)c1

InChI Key: InChIKey=CFGJHNBPHPDKTI-DMEZWZHPSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 212232   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM212232
PNG
(US9290490, 2-16)
Show SMILES CCC(=O)O[C@@H]1CCC(C[C@H]1C)C(C)(O)c1ncc(s1)-c1cc(C)cc(Nc2nccc(C)n2)c1 |r|
Show InChI InChI=1S/C27H34N4O3S/c1-6-24(32)34-22-8-7-20(13-17(22)3)27(5,33)25-29-15-23(35-25)19-11-16(2)12-21(14-19)31-26-28-10-9-18(4)30-26/h9-12,14-15,17,20,22,33H,6-8,13H2,1-5H3,(H,28,30,31)/t17-,20?,22-,27?/m1/s1
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PC cid
PC sid
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US Patent
n/an/a 93n/an/an/an/a7.525



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...

US Patent US9290490 (2016)


BindingDB Entry DOI: 10.7270/Q2Z0370B
More data for this
Ligand-Target Pair