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SMILES: Cc1nnc2CCc3cc(cc(F)c3-n12)-c1cncc(F)c1C1CC1

InChI Key: InChIKey=NBYBEBRAUKIPHN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 212442   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 11B1, mitochondrial (Homo sapiens (Human))	BDBM212442 (US9278093, 1) Show SMILES Cc1nnc2CCc3cc(cc(F)c3-n12)-c1cncc(F)c1C1CC1 Show InChI InChI=1S/C19H16F2N4/c1-10-23-24-17-5-4-12-6-13(7-15(20)19(12)25(10)17)14-8-22-9-16(21)18(14)11-2-3-11/h6-9,11H,2-5H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.29E+3	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp.; ElexoPharm GmbH US Patent					Assay Description Compounds of the Examples 1 to 3 were assayed for V79-Human-CYP11B2 and V79-Human-CYP11B1 by modifying the protocol described in J. Steroid Biochem. ...				US Patent US9278093 (2016) BindingDB Entry DOI: 10.7270/Q2HT2N5D
					More data for this Ligand-Target Pair
Cytochrome P450 11B2, mitochondrial (Homo sapiens (Human))	BDBM212442 (US9278093, 1) Show SMILES Cc1nnc2CCc3cc(cc(F)c3-n12)-c1cncc(F)c1C1CC1 Show InChI InChI=1S/C19H16F2N4/c1-10-23-24-17-5-4-12-6-13(7-15(20)19(12)25(10)17)14-8-22-9-16(21)18(14)11-2-3-11/h6-9,11H,2-5H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp.; ElexoPharm GmbH US Patent					Assay Description Compounds of the Examples 1 to 3 were assayed for V79-Human-CYP11B2 and V79-Human-CYP11B1 by modifying the protocol described in J. Steroid Biochem. ...				US Patent US9278093 (2016) BindingDB Entry DOI: 10.7270/Q2HT2N5D
					More data for this Ligand-Target Pair