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BDBM213213 N-(2-{[4-(4-Morpholinylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}ethyl)-2-propenamide (2)

SMILES: C=CC(=O)NCCNc1nc(CN2CCOCC2)cc(Nc2nc3cccnc3s2)n1

InChI Key: InChIKey=FQIOYIHUSLEZGR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 213213   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interlukin-2-inducible tyrosine kinase (Itk)


(Homo sapiens (Human))
BDBM213213
PNG
(N-(2-{[4-(4-Morpholinylmethyl)-6-([1,3]thiazolo[5,...)
Show SMILES C=CC(=O)NCCNc1nc(CN2CCOCC2)cc(Nc2nc3cccnc3s2)n1
Show InChI InChI=1S/C20H24N8O2S/c1-2-17(29)21-6-7-23-19-24-14(13-28-8-10-30-11-9-28)12-16(26-19)27-20-25-15-4-3-5-22-18(15)31-20/h2-5,12H,1,6-11,13H2,(H,21,29)(H2,23,24,25,26,27)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...


J Biol Chem 288: 28195-206 (2013)


Article DOI: 10.1074/jbc.M113.474114
BindingDB Entry DOI: 10.7270/Q2ZW1JSK
More data for this
Ligand-Target Pair