BDBM213673 US9278981, 265

SMILES: O[C@H]1CN(C[C@@H]1O)c1ncc(cc1-c1cncc(F)c1)C(=O)Nc1ccc(OC(F)(F)Cl)cc1

InChI Key: InChIKey=QIDUKMINDWSKNM-OALUTQOASA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 213673   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM213673 (US9278981, 265) Show SMILES O[C@H]1CN(C[C@@H]1O)c1ncc(cc1-c1cncc(F)c1)C(=O)Nc1ccc(OC(F)(F)Cl)cc1 |r| Show InChI InChI=1S/C22H18ClF3N4O4/c23-22(25,26)34-16-3-1-15(2-4-16)29-21(33)13-6-17(12-5-14(24)9-27-7-12)20(28-8-13)30-10-18(31)19(32)11-30/h1-9,18-19,31-32H,10-11H2,(H,29,33)/t18-,19-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.130	n/a	n/a	n/a	n/a	7.5	30
Novartis AG US Patent					Assay Description The assay plates were prepared by addition of 50 nL per well of compound solution in 90% DMSO. The kinase reactions were started by stepwise addition...				US Patent US9278981 (2016) BindingDB Entry DOI: 10.7270/Q2DV1HRD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM213673 (US9278981, 265) Show SMILES O[C@H]1CN(C[C@@H]1O)c1ncc(cc1-c1cncc(F)c1)C(=O)Nc1ccc(OC(F)(F)Cl)cc1 |r| Show InChI InChI=1S/C22H18ClF3N4O4/c23-22(25,26)34-16-3-1-15(2-4-16)29-21(33)13-6-17(12-5-14(24)9-27-7-12)20(28-8-13)30-10-18(31)19(32)11-30/h1-9,18-19,31-32H,10-11H2,(H,29,33)/t18-,19-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description For determination of ABL kinase activity, the radiometric filter-binding assay was used. The assay was performed by mixing 10 uL of the compound pre-...				US Patent US9278981 (2016) BindingDB Entry DOI: 10.7270/Q2DV1HRD
					More data for this Ligand-Target Pair