BDBM214646 US9284319, R4::US9730929, Example R4::US9783543, R4

SMILES: N(c1ccncc1)c1ccc2ncc(-c3ccncc3)n2n1

InChI Key: InChIKey=LIXUOPIKLSGXLR-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 214646   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GST-MKNK1 (Homo sapiens (Human))	BDBM214646 (US9284319, R4 | US9730929, Example R4 | US9783543,...) Show SMILES N(c1ccncc1)c1ccc2ncc(-c3ccncc3)n2n1 Show InChI InChI=1S/C16H12N6/c1-2-16-19-11-14(12-3-7-17-8-4-12)22(16)21-15(1)20-13-5-9-18-10-6-13/h1-11H,(H,18,20,21)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	245	n/a	n/a	n/a	n/a	7.5	22
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9284319 (2016) BindingDB Entry DOI: 10.7270/Q2765D6D
					More data for this Ligand-Target Pair
GST-MKNK1 (Homo sapiens (Human))	BDBM214646 (US9284319, R4 | US9730929, Example R4 | US9783543,...) Show SMILES N(c1ccncc1)c1ccc2ncc(-c3ccncc3)n2n1 Show InChI InChI=1S/C16H12N6/c1-2-16-19-11-14(12-3-7-17-8-4-12)22(16)21-15(1)20-13-5-9-18-10-6-13/h1-11H,(H,18,20,21)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	810	n/a	n/a	n/a	n/a	7.5	22
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9284319 (2016) BindingDB Entry DOI: 10.7270/Q2765D6D
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM214646 (US9284319, R4 | US9730929, Example R4 | US9783543,...) Show SMILES N(c1ccncc1)c1ccc2ncc(-c3ccncc3)n2n1 Show InChI InChI=1S/C16H12N6/c1-2-16-19-11-14(12-3-7-17-8-4-12)22(16)21-15(1)20-13-5-9-18-10-6-13/h1-11H,(H,18,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US9730929 (2017) BindingDB Entry DOI: 10.7270/Q28S4S1H
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM214646 (US9284319, R4 | US9730929, Example R4 | US9783543,...) Show SMILES N(c1ccncc1)c1ccc2ncc(-c3ccncc3)n2n1 Show InChI InChI=1S/C16H12N6/c1-2-16-19-11-14(12-3-7-17-8-4-12)22(16)21-15(1)20-13-5-9-18-10-6-13/h1-11H,(H,18,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9783543 (2017) BindingDB Entry DOI: 10.7270/Q2HM5BK4
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM214646 (US9284319, R4 | US9730929, Example R4 | US9783543,...) Show SMILES N(c1ccncc1)c1ccc2ncc(-c3ccncc3)n2n1 Show InChI InChI=1S/C16H12N6/c1-2-16-19-11-14(12-3-7-17-8-4-12)22(16)21-15(1)20-13-5-9-18-10-6-13/h1-11H,(H,18,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	245	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9783543 (2017) BindingDB Entry DOI: 10.7270/Q2HM5BK4
					More data for this Ligand-Target Pair