BDBM214700 US9296728, 23
SMILES: OC(=O)c1cc2ccc(cc2oc1=O)N(CC=C)CC=C
InChI Key: InChIKey=CNKJPGDJYDBWCI-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Monocarboxylate transporter 1 (MCT1) (Rattus norvegicus (Rat)) | BDBM214700 (US9296728, 23) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of MCT1 in rat brain endothelial 4 cells assessed as L-[14C]-Lactate Uptake after 15 mins by scintillation spectrometric analysis | Bioorg Med Chem Lett 26: 3282-3286 (2016) BindingDB Entry DOI: 10.7270/Q2BP04QP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 1 (MCT1) (Rattus norvegicus (Rat)) | BDBM214700 (US9296728, 23) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 250 | n/a | n/a | n/a | n/a | 7.43 | 37 |
Regents of the University of Minnesota US Patent | Assay Description The entire lactate uptake studies for the inhibition of MCT1 were carried out on RBE4 (Rat Brain Endothelial 4) cells. The expression of MCT1 on thes... | US Patent US9296728 (2016) BindingDB Entry DOI: 10.7270/Q2KH0M5R | |||||||||||
More data for this Ligand-Target Pair |