BDBM214744 Rhodanines, 32A

SMILES: Clc1cccc(c1)-c1ccc(\C=C2/SC(=S)N(Cc3nc4ccccc4[nH]3)C2=O)o1

InChI Key: InChIKey=QDUSTXCTSVDDMU-ODLFYWEKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 214744   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Microtubule-associated protein tau (TAU)(2N4R) (Homo sapiens (Human))	BDBM214744 (Rhodanines, 32A) Show SMILES Clc1cccc(c1)-c1ccc(\C=C2/SC(=S)N(Cc3nc4ccccc4[nH]3)C2=O)o1 Show InChI InChI=1S/C22H14ClN3O2S2/c23-14-5-3-4-13(10-14)18-9-8-15(28-18)11-19-21(27)26(22(29)30-19)12-20-24-16-6-1-2-7-17(16)25-20/h1-11H,12H2,(H,24,25)/b19-11-	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	7.4	n/a
The Ohio State University					Assay Description The Tau content of fractions was determined by dot blot analysis using nitrocellulose membranes (0.2 μm porosity) as described previously [Cisek...				J Biol Chem 288: 32599-611 (2013) Article DOI: 10.1074/jbc.M113.503474 BindingDB Entry DOI: 10.7270/Q2R49PMK
					More data for this Ligand-Target Pair