null
SMILES: CC#Cc1cncc(c1)-c1ccc(F)c(c1)[C@]1(CF)C[C@H](OC(N)=N1)C(F)(F)F
InChI Key: InChIKey=DHWUQWORXAPEQU-PKOBYXMFSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (Homo sapiens (Human)) | BDBM214905 (US9296734, 104) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | 37 |
Amgen Inc. US Patent | Assay Description The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ... | US Patent US9296734 (2016) BindingDB Entry DOI: 10.7270/Q2DR2TB3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin D (Homo sapiens (Human)) | BDBM214905 (US9296734, 104) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20E+5 | n/a | n/a | n/a | n/a | 3.5 | n/a |
Amgen Inc. US Patent | Assay Description Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ... | US Patent US9296734 (2016) BindingDB Entry DOI: 10.7270/Q2DR2TB3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM214905 (US9296734, 104) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 318 | n/a | n/a | n/a | n/a | 4.2 | n/a |
Amgen Inc. US Patent | Assay Description The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic... | US Patent US9296734 (2016) BindingDB Entry DOI: 10.7270/Q2DR2TB3 | |||||||||||
More data for this Ligand-Target Pair |