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SMILES: C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CN(c2cccnc2)S(C)(=O)=O)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1

InChI Key: InChIKey=NPCJFISSBFPCIE-WNNCOPHBSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 215320   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188]


(Homo sapiens (Human))		BDBM215320
PNG
(US9296736, 282)
Show SMILES C[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CN(c2cccnc2)S(C)(=O)=O)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C31H33Cl2N3O5S/c1-31(17-28(37)38)16-26(22-5-3-6-24(33)15-22)29(21-10-12-23(32)13-11-21)36(30(31)39)27(20-8-9-20)19-35(42(2,40)41)25-7-4-14-34-18-25/h3-7,10-15,18,20,26-27,29H,8-9,16-17,19H2,1-2H3,(H,37,38)/t26-,27-,29-,31-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...

US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair