BDBM215362 US9296736, 330::US9593129, Example 330

SMILES: CCCS(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](CC)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key: InChIKey=IPBOIDRBRXAVJG-GCMXZSHTSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 215362   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (aa 1-188) (Homo sapiens (Human))	BDBM215362 (US9296736, 330 | US9593129, Example 330) Show SMILES CCCS(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](CC)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 Show InChI InChI=1S/C29H35Cl2NO5S/c1-3-14-38(36,37)18-25(19-8-9-19)32-27(20-10-12-22(30)13-11-20)24(21-6-5-7-23(31)15-21)16-29(4-2,28(32)35)17-26(33)34/h5-7,10-13,15,19,24-25,27H,3-4,8-9,14,16-18H2,1-2H3,(H,33,34)/t24-,25-,27-,29-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9593129 (2017) BindingDB Entry DOI: 10.7270/Q20P1232
					More data for this Ligand-Target Pair
MDM2 and p53 (Homo sapiens (Human))	BDBM215362 (US9296736, 330 | US9593129, Example 330) Show SMILES CCCS(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](CC)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 Show InChI InChI=1S/C29H35Cl2NO5S/c1-3-14-38(36,37)18-25(19-8-9-19)32-27(20-10-12-22(30)13-11-20)24(21-6-5-7-23(31)15-21)16-29(4-2,28(32)35)17-26(33)34/h5-7,10-13,15,19,24-25,27H,3-4,8-9,14,16-18H2,1-2H3,(H,33,34)/t24-,25-,27-,29-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	25
Amgen INC. US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9296736 (2016) BindingDB Entry DOI: 10.7270/Q29022M2
					More data for this Ligand-Target Pair