BDBM217352 GS-9820

SMILES: C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1

InChI Key:

Data: 11 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 217352   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Mus musculus (Mouse))	BDBM217352 (GS-9820) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.44E+3	n/a	n/a	n/a	n/a	n/a	n/a
Western University					Assay Description Biochemical in vitro lipid kinase assays were performed by the SelectScreen® biochemical kinase assay service (Invitrogen Ltd.). A stock solution of ...				J Biol Chem 288: 35346-57 (2013) Article DOI: 10.1074/jbc.M113.507525 BindingDB Entry DOI: 10.7270/Q28051F7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Mus musculus (Mouse))	BDBM217352 (GS-9820) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Western University					Assay Description Biochemical in vitro lipid kinase assays were performed by the SelectScreen® biochemical kinase assay service (Invitrogen Ltd.). A stock solution of ...				J Biol Chem 288: 35346-57 (2013) Article DOI: 10.1074/jbc.M113.507525 BindingDB Entry DOI: 10.7270/Q28051F7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Mus musculus (Mouse))	BDBM217352 (GS-9820) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Western University					Assay Description Biochemical in vitro lipid kinase assays were performed by the SelectScreen® biochemical kinase assay service (Invitrogen Ltd.). A stock solution of ...				J Biol Chem 288: 35346-57 (2013) Article DOI: 10.1074/jbc.M113.507525 BindingDB Entry DOI: 10.7270/Q28051F7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Mus musculus (Mouse))	BDBM217352 (GS-9820) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	12.7	n/a	n/a	n/a	n/a	n/a	n/a
Western University					Assay Description Biochemical in vitro lipid kinase assays were performed by the SelectScreen® biochemical kinase assay service (Invitrogen Ltd.). A stock solution of ...				J Biol Chem 288: 35346-57 (2013) Article DOI: 10.1074/jbc.M113.507525 BindingDB Entry DOI: 10.7270/Q28051F7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Mus musculus (Mouse))	BDBM217352 (GS-9820) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Western University					Assay Description Biochemical in vitro lipid kinase assays were performed by the SelectScreen® biochemical kinase assay service (Invitrogen Ltd.). A stock solution of ...				J Biol Chem 288: 35346-57 (2013) Article DOI: 10.1074/jbc.M113.507525 BindingDB Entry DOI: 10.7270/Q28051F7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM217352 (GS-9820) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit (Mus musculus (Mouse))	BDBM217352 (GS-9820) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.87E+4	n/a	n/a	n/a	n/a	n/a	n/a
Western University					Assay Description Biochemical in vitro lipid kinase assays were performed by the SelectScreen® biochemical kinase assay service (Invitrogen Ltd.). A stock solution of ...				J Biol Chem 288: 35346-57 (2013) Article DOI: 10.1074/jbc.M113.507525 BindingDB Entry DOI: 10.7270/Q28051F7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Mus musculus (Mouse))	BDBM217352 (GS-9820) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Western University					Assay Description Biochemical in vitro lipid kinase assays were performed by the SelectScreen® biochemical kinase assay service (Invitrogen Ltd.). A stock solution of ...				J Biol Chem 288: 35346-57 (2013) Article DOI: 10.1074/jbc.M113.507525 BindingDB Entry DOI: 10.7270/Q28051F7
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM217352 (GS-9820) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Ain Shams University Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta (unknown origin)				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111718
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM217352 (GS-9820) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of GST-tagged PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 2 hrs followed by ATP addition measured after 30 mins by...				J Med Chem 62: 4783-4814 (2019) Article DOI: 10.1021/acs.jmedchem.8b01298
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3 (Homo sapiens (Human))	BDBM217352 (GS-9820) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of Vps34 (unknown origin)				J Med Chem 62: 4783-4814 (2019) Article DOI: 10.1021/acs.jmedchem.8b01298
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (Mus musculus (Mouse))	BDBM217352 (GS-9820) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Western University					Assay Description Biochemical in vitro lipid kinase assays were performed by the SelectScreen® biochemical kinase assay service (Invitrogen Ltd.). A stock solution of ...				J Biol Chem 288: 35346-57 (2013) Article DOI: 10.1074/jbc.M113.507525 BindingDB Entry DOI: 10.7270/Q28051F7
					More data for this Ligand-Target Pair