BindingDB PrimarySearch

BDBM21865 (14beta)-17-(cyclopropylmethyl)-18-(1-hydroxy-1-methylethyl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol::(1S,2R,6S)-3-(cyclopropylmethyl)-16-(2-hydroxypropan-2-yl)-15-methoxy-13-oxa-3-azahexacyclo[13.2.2.1^{2,8}.0^{1,6}.0^{6,14}.0^{7,12}]icosa-7,9,11-trien-11-ol::CHEMBL24995::Diprenorphine::[3H]-diprenorphine

SMILES: [H][C@]12Cc3ccc(O)c4OC5[C@](CCN1CC1CC1)(c34)[C@@]21CCC5(OC)C(C1)C(C)(C)O

InChI Key: InChIKey=OIJXLIIMXHRJJH-USQHPYHMSA-N

Data: 9 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 21865
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mu-type opioid receptor (MOUSE)	BDBM21865 ((14beta)-17-(cyclopropylmethyl)-18-(1-hydroxy-1-me...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid UniChem Similars	PubMed	0.0300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Memorial Sloan-Kettering Cancer Center Curated by PDSP K_i Database									J Pharmacol Exp Ther 286: 1007-13 (1998) BindingDB Entry DOI: 10.7270/Q2QC022N
					More data for this Ligand-Target Pair
Mu-type opioid receptor (MOUSE)	BDBM21865 ((14beta)-17-(cyclopropylmethyl)-18-(1-hydroxy-1-me...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid UniChem Similars	PubMed	0.120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Memorial Sloan-Kettering Cancer Center Curated by PDSP K_i Database									J Pharmacol Exp Ther 286: 1007-13 (1998) BindingDB Entry DOI: 10.7270/Q2QC022N
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM21865 ((14beta)-17-(cyclopropylmethyl)-18-(1-hydroxy-1-me...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid UniChem Similars	PubMed	0.180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by PDSP K_i Database									J Pharmacol Exp Ther 272: 423-8 (1995) BindingDB Entry DOI: 10.7270/Q2TM78M9
University of Pennsylvania Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM21865 ((14beta)-17-(cyclopropylmethyl)-18-(1-hydroxy-1-me...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid UniChem Similars	PubMed	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Memorial Sloan-Kettering Cancer Center Curated by PDSP K_i Database									J Pharmacol Exp Ther 270: 1246-55 (1994) BindingDB Entry DOI: 10.7270/Q2CF9NN9
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM21865 ((14beta)-17-(cyclopropylmethyl)-18-(1-hydroxy-1-me...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid UniChem Similars	PubMed	0.290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Memorial Sloan-Kettering Cancer Center Curated by PDSP K_i Database									J Pharmacol Exp Ther 270: 1246-55 (1994) BindingDB Entry DOI: 10.7270/Q2CF9NN9
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM21865 ((14beta)-17-(cyclopropylmethyl)-18-(1-hydroxy-1-me...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid UniChem Similars	PubMed	0.590	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Memorial Sloan-Kettering Cancer Center Curated by PDSP K_i Database									J Pharmacol Exp Ther 270: 1246-55 (1994) BindingDB Entry DOI: 10.7270/Q2CF9NN9
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM21865 ((14beta)-17-(cyclopropylmethyl)-18-(1-hydroxy-1-me...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NIDA Addiction Research Center Curated by PDSP K_i Database									Life Sci 45: 1821-9 (1989) Article DOI: 10.1016/0024-3205(89)90523-7 BindingDB Entry DOI: 10.7270/Q20Z71SN
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Rattus norvegicus (rat))	BDBM21865 ((14beta)-17-(cyclopropylmethyl)-18-(1-hydroxy-1-me...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NIDA Addiction Research Center Curated by PDSP K_i Database									Life Sci 45: 1821-9 (1989) Article DOI: 10.1016/0024-3205(89)90523-7 BindingDB Entry DOI: 10.7270/Q20Z71SN
					More data for this Ligand-Target Pair
Opioid receptors; mu & delta (Rattus norvegicus (rat))	BDBM21865 ((14beta)-17-(cyclopropylmethyl)-18-(1-hydroxy-1-me...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL DrugBank PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NIDA Addiction Research Center Curated by PDSP K_i Database									Life Sci 45: 1821-9 (1989) Article DOI: 10.1016/0024-3205(89)90523-7 BindingDB Entry DOI: 10.7270/Q20Z71SN
					More data for this Ligand-Target Pair