null

SMILES: COc1nc2ccc(cc2c(Cl)c1Cc1ccc(nc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F

InChI Key: InChIKey=RTUAJPWIBYTPMS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 220249   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform 2 of Nuclear receptor ROR-gamma (RORgT) (Homo sapiens (Human))	BDBM220249 (US9290476, 94A | US9290476, 94B | US9290476, 94C) Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(nc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F Show InChI InChI=1S/C28H20ClF6N5O2/c1-40-14-36-13-23(40)26(41,17-5-8-22(38-12-17)28(33,34)35)16-4-6-20-18(10-16)24(29)19(25(39-20)42-2)9-15-3-7-21(37-11-15)27(30,31)32/h3-8,10-14,41H,9H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	12	n/a	n/a	n/a	7.0	1
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...				US Patent US9290476 (2016) BindingDB Entry DOI: 10.7270/Q2M61J3M
					More data for this Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma (RORgT) (Homo sapiens (Human))	BDBM220249 (US9290476, 94A | US9290476, 94B | US9290476, 94C) Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(nc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F Show InChI InChI=1S/C28H20ClF6N5O2/c1-40-14-36-13-23(40)26(41,17-5-8-22(38-12-17)28(33,34)35)16-4-6-20-18(10-16)24(29)19(25(39-20)42-2)9-15-3-7-21(37-11-15)27(30,31)32/h3-8,10-14,41H,9H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	6.5	n/a	n/a	n/a	7.0	1
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...				US Patent US9290476 (2016) BindingDB Entry DOI: 10.7270/Q2M61J3M
					More data for this Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma (RORgT) (Homo sapiens (Human))	BDBM220249 (US9290476, 94A | US9290476, 94B | US9290476, 94C) Show SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(nc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F Show InChI InChI=1S/C28H20ClF6N5O2/c1-40-14-36-13-23(40)26(41,17-5-8-22(38-12-17)28(33,34)35)16-4-6-20-18(10-16)24(29)19(25(39-20)42-2)9-15-3-7-21(37-11-15)27(30,31)32/h3-8,10-14,41H,9H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	98	n/a	n/a	n/a	7.0	1
JANSSEN PHARMACEUTICA NV US Patent					Assay Description Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...				US Patent US9290476 (2016) BindingDB Entry DOI: 10.7270/Q2M61J3M
					More data for this Ligand-Target Pair