BDBM220383 US9290488, ZA04

SMILES: N[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O

InChI Key: InChIKey=YUONSNDROGRPQU-HBOOAYOWSA-N

Data: 4 KI  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 220383   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Opioid growth factor receptor-like protein 1 (Homo sapiens (Human))	BDBM220383 (US9290488, ZA04) Show SMILES N[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O |r,THB:26:25:17.18.24:20.22.21| Show InChI InChI=1S/C30H41N5O3/c31-24-17-33(27(24)30(37)38)28-29(36)35(26-11-4-3-10-25(26)32-28)23-15-20-8-5-9-21(16-23)34(20)22-13-18-6-1-2-7-19(12-18)14-22/h3-4,10-11,18-24,27H,1-2,5-9,12-17,31H2,(H,37,38)/t18-,19+,20-,21+,22-,23+,24-,27+/m1/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.98	-11.9	n/a	n/a	n/a	n/a	n/a	7.4	25
Purdue Pharma L.P. US Patent					Assay Description Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 μg membrane protein in a ...				US Patent US9290488 (2016) BindingDB Entry DOI: 10.7270/Q2GF0SCW
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM220383 (US9290488, ZA04) Show SMILES N[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O |r,THB:26:25:17.18.24:20.22.21| Show InChI InChI=1S/C30H41N5O3/c31-24-17-33(27(24)30(37)38)28-29(36)35(26-11-4-3-10-25(26)32-28)23-15-20-8-5-9-21(16-23)34(20)22-13-18-6-1-2-7-19(12-18)14-22/h3-4,10-11,18-24,27H,1-2,5-9,12-17,31H2,(H,37,38)/t18-,19+,20-,21+,22-,23+,24-,27+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	11.6	-10.8	n/a	n/a	n/a	n/a	n/a	7.4	25
Purdue Pharma L.P. US Patent					Assay Description Radioligand dose displacement assays used 0.4-0.8 nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 μg membrane protein (recombinant kappa opioid rece...				US Patent US9290488 (2016) BindingDB Entry DOI: 10.7270/Q2GF0SCW
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM220383 (US9290488, ZA04) Show SMILES N[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O |r,THB:26:25:17.18.24:20.22.21| Show InChI InChI=1S/C30H41N5O3/c31-24-17-33(27(24)30(37)38)28-29(36)35(26-11-4-3-10-25(26)32-28)23-15-20-8-5-9-21(16-23)34(20)22-13-18-6-1-2-7-19(12-18)14-22/h3-4,10-11,18-24,27H,1-2,5-9,12-17,31H2,(H,37,38)/t18-,19+,20-,21+,22-,23+,24-,27+/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	83	-9.65	n/a	n/a	n/a	n/a	n/a	7.4	25
Purdue Pharma L.P. US Patent					Assay Description Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-receptors (Perkin Elmer, Shelton, Conn.). Radioligand ...				US Patent US9290488 (2016) BindingDB Entry DOI: 10.7270/Q2GF0SCW
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM220383 (US9290488, ZA04) Show SMILES N[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O |r,THB:26:25:17.18.24:20.22.21| Show InChI InChI=1S/C30H41N5O3/c31-24-17-33(27(24)30(37)38)28-29(36)35(26-11-4-3-10-25(26)32-28)23-15-20-8-5-9-21(16-23)34(20)22-13-18-6-1-2-7-19(12-18)14-22/h3-4,10-11,18-24,27H,1-2,5-9,12-17,31H2,(H,37,38)/t18-,19+,20-,21+,22-,23+,24-,27+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>2.00E+4	>-6.41	n/a	n/a	n/a	n/a	n/a	7.4	25
Purdue Pharma L.P. US Patent					Assay Description Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 μg membrane protein (recombinant delta opioid re...				US Patent US9290488 (2016) BindingDB Entry DOI: 10.7270/Q2GF0SCW
					More data for this Ligand-Target Pair
Opioid growth factor receptor-like protein 1 (Homo sapiens (Human))	BDBM220383 (US9290488, ZA04) Show SMILES N[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O |r,THB:26:25:17.18.24:20.22.21| Show InChI InChI=1S/C30H41N5O3/c31-24-17-33(27(24)30(37)38)28-29(36)35(26-11-4-3-10-25(26)32-28)23-15-20-8-5-9-21(16-23)34(20)22-13-18-6-1-2-7-19(12-18)14-22/h3-4,10-11,18-24,27H,1-2,5-9,12-17,31H2,(H,37,38)/t18-,19+,20-,21+,22-,23+,24-,27+/m1/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.84	n/a	n/a	7.4	25
Purdue Pharma L.P. US Patent					Assay Description ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...				US Patent US9290488 (2016) BindingDB Entry DOI: 10.7270/Q2GF0SCW
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM220383 (US9290488, ZA04) Show SMILES N[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O |r,THB:26:25:17.18.24:20.22.21| Show InChI InChI=1S/C30H41N5O3/c31-24-17-33(27(24)30(37)38)28-29(36)35(26-11-4-3-10-25(26)32-28)23-15-20-8-5-9-21(16-23)34(20)22-13-18-6-1-2-7-19(12-18)14-22/h3-4,10-11,18-24,27H,1-2,5-9,12-17,31H2,(H,37,38)/t18-,19+,20-,21+,22-,23+,24-,27+/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>2.00E+4	n/a	n/a	7.4	25
Purdue Pharma L.P. US Patent					Assay Description [35S]GTPγS functional assays were conducted using freshly thawed membranes expressing human μ-receptors. Assay reactions were prepared by se...				US Patent US9290488 (2016) BindingDB Entry DOI: 10.7270/Q2GF0SCW
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM220383 (US9290488, ZA04) Show SMILES N[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O |r,THB:26:25:17.18.24:20.22.21| Show InChI InChI=1S/C30H41N5O3/c31-24-17-33(27(24)30(37)38)28-29(36)35(26-11-4-3-10-25(26)32-28)23-15-20-8-5-9-21(16-23)34(20)22-13-18-6-1-2-7-19(12-18)14-22/h3-4,10-11,18-24,27H,1-2,5-9,12-17,31H2,(H,37,38)/t18-,19+,20-,21+,22-,23+,24-,27+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>2.00E+4	n/a	n/a	7.4	25
Purdue Pharma L.P. US Patent					Assay Description Kappa opioid receptor membrane solution was prepared by sequentially adding final concentrations of 0.026 μg/μL kappa membrane protein (in-hous...				US Patent US9290488 (2016) BindingDB Entry DOI: 10.7270/Q2GF0SCW
					More data for this Ligand-Target Pair