BDBM221444 US9303023, 141

SMILES: COc1cc(OC)nc(n1)N1CCCC1Cn1cc(NC(=O)c2ncoc2-c2cccc(C)c2)cn1

InChI Key: InChIKey=BYHLJVNQNBXWBE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221444   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221444 (US9303023, 141) Show SMILES COc1cc(OC)nc(n1)N1CCCC1Cn1cc(NC(=O)c2ncoc2-c2cccc(C)c2)cn1 Show InChI InChI=1S/C25H27N7O4/c1-16-6-4-7-17(10-16)23-22(26-15-36-23)24(33)28-18-12-27-31(13-18)14-19-8-5-9-32(19)25-29-20(34-2)11-21(30-25)35-3/h4,6-7,10-13,15,19H,5,8-9,14H2,1-3H3,(H,28,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair