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SMILES: Cc1csc(n1)-c1n2CCNC(c3ccc(Cl)o3)c2c2n(C)c(=O)n(C)c(=O)c12

InChI Key: InChIKey=CZEJXHBNGHIMJV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221958   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cystic fibrosis transmembrane conductance regulator


(Cricetulus griseus (Chinese hamster))		BDBM221958
PNG
(US9303035, 1.26)
Show SMILES Cc1csc(n1)-c1n2CCNC(c3ccc(Cl)o3)c2c2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C19H18ClN5O3S/c1-9-8-29-17(22-9)15-12-14(23(2)19(27)24(3)18(12)26)16-13(21-6-7-25(15)16)10-4-5-11(20)28-10/h4-5,8,13,21H,6-7H2,1-3H3
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...

US Patent US9303035 (2016)


BindingDB Entry DOI: 10.7270/Q2SQ8Z7R
More data for this
Ligand-Target Pair