BDBM221969 US9303035, 3.1

SMILES: Cn1c2c3C(NCCn3c(-c3cccc(Cl)c3)c2c(=O)n(C)c1=O)c1ccc(Cl)o1

InChI Key: InChIKey=AQRRSZYKWWEJTD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221969   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cystic fibrosis transmembrane conductance regulator protein (CFTR) (Cricetulus griseus (Chinese hamster))	BDBM221969 (US9303035, 3.1) Show SMILES Cn1c2c3C(NCCn3c(-c3cccc(Cl)c3)c2c(=O)n(C)c1=O)c1ccc(Cl)o1 Show InChI InChI=1S/C21H18Cl2N4O3/c1-25-18-15(20(28)26(2)21(25)29)17(11-4-3-5-12(22)10-11)27-9-8-24-16(19(18)27)13-6-7-14(23)30-13/h3-7,10,16,24H,8-9H2,1-2H3	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...				US Patent US9303035 (2016) BindingDB Entry DOI: 10.7270/Q2SQ8Z7R
					More data for this Ligand-Target Pair