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SMILES: Cc1ccc(o1)C1OCCn2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1ccccc1

InChI Key: InChIKey=BPLPHDCYSOFWAG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 221978   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Cricetulus griseus (Chinese hamster))	BDBM221978 (US9303035, 4.1 | US9303035, 4.3) Show SMILES Cc1ccc(o1)C1OCCn2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1ccccc1 Show InChI InChI=1S/C22H21N3O4/c1-13-9-10-15(29-13)20-19-18-16(21(26)24(3)22(27)23(18)2)17(25(19)11-12-28-20)14-7-5-4-6-8-14/h4-10,20H,11-12H2,1-3H3	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.16	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...				US Patent US9303035 (2016) BindingDB Entry DOI: 10.7270/Q2SQ8Z7R
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Cricetulus griseus (Chinese hamster))	BDBM221978 (US9303035, 4.1 | US9303035, 4.3) Show SMILES Cc1ccc(o1)C1OCCn2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1ccccc1 Show InChI InChI=1S/C22H21N3O4/c1-13-9-10-15(29-13)20-19-18-16(21(26)24(3)22(27)23(18)2)17(25(19)11-12-28-20)14-7-5-4-6-8-14/h4-10,20H,11-12H2,1-3H3	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.23	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...				US Patent US9303035 (2016) BindingDB Entry DOI: 10.7270/Q2SQ8Z7R
					More data for this Ligand-Target Pair