BDBM222534 US9315489, 70

SMILES: FC(F)(F)Oc1ccc(NC(=O)c2ccnc(c2)-c2cncnc2)cc1

InChI Key: InChIKey=FDQWXOAYUMKODC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 222534   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM222534 (US9315489, 70) Show SMILES FC(F)(F)Oc1ccc(NC(=O)c2ccnc(c2)-c2cncnc2)cc1 Show InChI InChI=1S/C17H11F3N4O2/c18-17(19,20)26-14-3-1-13(2-4-14)24-16(25)11-5-6-23-15(7-11)12-8-21-10-22-9-12/h1-10H,(H,24,25)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description For determination of ABL kinase activity, the radiometric filter-binding assay was used. The assay was performed by mixing 10 μL of the compound p...				US Patent US9315489 (2016) BindingDB Entry DOI: 10.7270/Q2H130WD
					More data for this Ligand-Target Pair