BDBM222735 US9315498, 23

SMILES: O=C1O[C@H]2CCC[C@H]2N1c1ccc(cn1)C#Cc1cccnc1

InChI Key: InChIKey=HAEBUCVVJXTEGX-CVEARBPZSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 222735   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5a (mGluR5) (Homo sapiens (Human))	BDBM222735 (US9315498, 23) Show SMILES O=C1O[C@H]2CCC[C@H]2N1c1ccc(cn1)C#Cc1cccnc1 |r| Show InChI InChI=1S/C18H15N3O2/c22-18-21(15-4-1-5-16(15)23-18)17-9-8-14(12-20-17)7-6-13-3-2-10-19-11-13/h2-3,8-12,15-16H,1,4-5H2/t15-,16+/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	37
HOFFMAN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9315498 (2016) BindingDB Entry DOI: 10.7270/Q23T9G2X
					More data for this Ligand-Target Pair