BDBM222746 US9315498, 34

SMILES: CC1(C)CN(C(=O)O1)c1ccc(cn1)C#Cc1cc(F)ccc1F

InChI Key: InChIKey=XOUVHFBEGYPDIX-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 222746   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5a (mGluR5) (Homo sapiens (Human))	BDBM222746 (US9315498, 34) Show SMILES CC1(C)CN(C(=O)O1)c1ccc(cn1)C#Cc1cc(F)ccc1F Show InChI InChI=1S/C18H14F2N2O2/c1-18(2)11-22(17(23)24-18)16-8-4-12(10-21-16)3-5-13-9-14(19)6-7-15(13)20/h4,6-10H,11H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	37
HOFFMAN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9315498 (2016) BindingDB Entry DOI: 10.7270/Q23T9G2X
					More data for this Ligand-Target Pair