BDBM222794 US9315498, 84

SMILES: CN1C2CCCCC2N(C1=O)c1ccc(cn1)C#Cc1ccccc1

InChI Key: InChIKey=NEJNZWMONLOGMV-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 222794   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5a (mGluR5) (Homo sapiens (Human))	BDBM222794 (US9315498, 84) Show SMILES CN1C2CCCCC2N(C1=O)c1ccc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C21H21N3O/c1-23-18-9-5-6-10-19(18)24(21(23)25)20-14-13-17(15-22-20)12-11-16-7-3-2-4-8-16/h2-4,7-8,13-15,18-19H,5-6,9-10H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	37
HOFFMAN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9315498 (2016) BindingDB Entry DOI: 10.7270/Q23T9G2X
					More data for this Ligand-Target Pair