BDBM222883 US9315498, 169

SMILES: COC1CN(C(=O)OC1(C)C)c1ccc(cn1)C#Cc1cccc(F)c1

InChI Key: InChIKey=RORTXKIKOLHPKX-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 222883   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5a (mGluR5) (Homo sapiens (Human))	BDBM222883 (US9315498, 169) Show SMILES COC1CN(C(=O)OC1(C)C)c1ccc(cn1)C#Cc1cccc(F)c1 Show InChI InChI=1S/C20H19FN2O3/c1-20(2)17(25-3)13-23(19(24)26-20)18-10-9-15(12-22-18)8-7-14-5-4-6-16(21)11-14/h4-6,9-12,17H,13H2,1-3H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	37
HOFFMAN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9315498 (2016) BindingDB Entry DOI: 10.7270/Q23T9G2X
					More data for this Ligand-Target Pair