BDBM222966 US9315514, 7
SMILES: CC(C)(C)[C@@]1(C)OCO[C@]23CC[C@@]4(C[C@H]12)[C@H]1Cc2ccc(OCc5ccccc5)c5O[C@@H]3[C@]4(CCN1CC1CC1)c25
InChI Key: InChIKey=GMWKLQVLCZTICI-BHPNABNESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM222966![]() (US9315514, 7) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | 757 | -8.34 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Rhodes Technologies US Patent | Assay Description Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recombin... | US Patent US9315514 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DWC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM222966![]() (US9315514, 7) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >2.00E+4 | n/a | n/a | 7.4 | 25 |
Rhodes Technologies US Patent | Assay Description Functional [35S]GTPγS binding assays were conducted as follows. κ opioid receptor membrane solution was prepared by sequentially adding f... | US Patent US9315514 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DWC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM222966![]() (US9315514, 7) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 950 | n/a | n/a | 7.4 | 25 |
Rhodes Technologies US Patent | Assay Description [35S]GTPγS functional assays were conducted using freshly thawed μ-receptor membranes prepared in-house from a cell line expressing recombin... | US Patent US9315514 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DWC | |||||||||||
More data for this Ligand-Target Pair |