BDBM224496 US10080750, Compound 174::US9321760, 174::US9662330, Compound 174
SMILES: NCC(N1CCN(CC1)c1ncnc(N)c1-c1ccc(F)cc1)c1ccc(Cl)nc1
InChI Key: InChIKey=HRDNQTRURDVWED-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ribosomal protein S6 kinase (P70S6K) (Homo sapiens (Human)) | BDBM224496 (US10080750, Compound 174 | US9321760, 174 | US9662...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Merck Patent GmbH US Patent | Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... | US Patent US9321760 (2016) BindingDB Entry DOI: 10.7270/Q2R78D2R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase (P70S6K) (Homo sapiens (Human)) | BDBM224496 (US10080750, Compound 174 | US9321760, 174 | US9662...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Patent GmbH US Patent | Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... | US Patent US9662330 (2017) BindingDB Entry DOI: 10.7270/Q2MK6G04 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P70S6K (T412E) (Homo sapiens (Human)) | BDBM224496 (US10080750, Compound 174 | US9321760, 174 | US9662...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Merck Patent GmbH US Patent | Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... | US Patent US10080750 (2018) BindingDB Entry DOI: 10.7270/Q2WS8W9F | |||||||||||
More data for this Ligand-Target Pair |