BDBM224575 US10202383, Example 2(12)::US9321791, 2(12)::US9556175, 2(12)

SMILES: Cn1c(=O)n(CC#C)c2nc(N3CCCC(N)C3)n(Cc3ccccc3C#N)c2c1=O

InChI Key: InChIKey=GZNMBSZOSKYOCZ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 224575   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM224575 (US10202383, Example 2(12) | US9321791, 2(12) | US9...) Show SMILES Cn1c(=O)n(CC#C)c2nc(N3CCCC(N)C3)n(Cc3ccccc3C#N)c2c1=O Show InChI InChI=1S/C22H23N7O2/c1-3-10-28-19-18(20(30)26(2)22(28)31)29(13-16-8-5-4-7-15(16)12-23)21(25-19)27-11-6-9-17(24)14-27/h1,4-5,7-8,17H,6,9-11,13-14,24H2,2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.8	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description 50 μl substrate solution (AFC; AFC is amido-4-trifluoromethylcoumarin), final concentration 100 μM, were placed in black microtitre plates. 20 ...				US Patent US9321791 (2016) BindingDB Entry DOI: 10.7270/Q2GQ6WNR
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM224575 (US10202383, Example 2(12) | US9321791, 2(12) | US9...) Show SMILES Cn1c(=O)n(CC#C)c2nc(N3CCCC(N)C3)n(Cc3ccccc3C#N)c2c1=O Show InChI InChI=1S/C22H23N7O2/c1-3-10-28-19-18(20(30)26(2)22(28)31)29(13-16-8-5-4-7-15(16)12-23)21(25-19)27-11-6-9-17(24)14-27/h1,4-5,7-8,17H,6,9-11,13-14,24H2,2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description 50 μl substrate solution (AFC; AFC is amido-4-trifluoromethylcoumarin), final concentration 100 μM, were placed in black microtitre plates....				US Patent US10202383 (2019) BindingDB Entry DOI: 10.7270/Q2P55QNN
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM224575 (US10202383, Example 2(12) | US9321791, 2(12) | US9...) Show SMILES Cn1c(=O)n(CC#C)c2nc(N3CCCC(N)C3)n(Cc3ccccc3C#N)c2c1=O Show InChI InChI=1S/C22H23N7O2/c1-3-10-28-19-18(20(30)26(2)22(28)31)29(13-16-8-5-4-7-15(16)12-23)21(25-19)27-11-6-9-17(24)14-27/h1,4-5,7-8,17H,6,9-11,13-14,24H2,2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.8	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description 50 μl substrate solution (AFC; AFC is amido-4-trifluoromethylcoumarin), final concentration 100 μM, were placed in black microtitre plates....				US Patent US9556175 (2017) BindingDB Entry DOI: 10.7270/Q2Z03B5T
					More data for this Ligand-Target Pair