BDBM225298 2-((8-Methyl-2-morpholino-4-oxo-4H-benzo[e][1,3]oxazin-7-yl)oxy)-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)acetamide (7d)

SMILES: Cc1c(OCC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)ccc2c1oc(nc2=O)N1CCOCC1

InChI Key: InChIKey=ALALNSMNEINQHD-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 225298   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA-dependent protein kinase catalytic subunit (Homo sapiens (Human))	BDBM225298 (2-((8-Methyl-2-morpholino-4-oxo-4H-benzo[e][1,3]ox...) Show SMILES Cc1c(OCC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)ccc2c1oc(nc2=O)N1CCOCC1 Show InChI InChI=1S/C24H23N5O7S2/c1-15-19(7-6-18-21(15)36-24(27-22(18)31)29-9-11-34-12-10-29)35-14-20(30)26-16-2-4-17(5-3-16)38(32,33)28-23-25-8-13-37-23/h2-8,13H,9-12,14H2,1H3,(H,25,28)(H,26,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Taibah University					Assay Description The assays of DNA-PK were performed by Reaction Biology Corporation, One Great Valley Parkway, Suite 2 Malvern, PA 19355 USA. All Compounds were diss...				Bioorg Chem 72: 234-247 (2017) BindingDB Entry DOI: 10.7270/Q2930S2V
					More data for this Ligand-Target Pair