BDBM22579 AICAR::Aminoimidazole-4-carboxamide ribonucleotide::CHEMBL483849::ZMP::{[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
SMILES: NC(=O)c1ncn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c1N
InChI Key: InChIKey=NOTGFIUVDGNKRI-UUOKFMHZSA-N
PDB links: 10 PDB IDs match this monomer. 4 PDB IDs contain this monomer as substructures. 4 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fructose-1,6-bisphosphatase 1 (FBPase) (Homo sapiens (Human)) | BDBM22579 (AICAR | Aminoimidazole-4-carboxamide ribonucleotid...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry | J Med Chem 52: 2880-98 (2009) Article DOI: 10.1021/jm900078f BindingDB Entry DOI: 10.7270/Q2V40V20 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C-interacting protein 1 (Rattus norvegicus) | BDBM22579 (AICAR | Aminoimidazole-4-carboxamide ribonucleotid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.20E+6 | n/a | n/a | n/a | n/a | n/a |
University of Maryland Curated by ChEMBL | Assay Description Binding affinity to mouse HINT1 by HSQC spectra assay | Bioorg Med Chem 18: 6756-62 (2010) Article DOI: 10.1016/j.bmc.2010.07.051 BindingDB Entry DOI: 10.7270/Q2ZP472H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C-interacting protein 1 (Rattus norvegicus) | BDBM22579 (AICAR | Aminoimidazole-4-carboxamide ribonucleotid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.10E+6 | n/a | n/a | n/a | n/a | n/a |
University of Maryland Curated by ChEMBL | Assay Description Binding affinity to mouse HINT1 by fluorescence quenching assay | Bioorg Med Chem 18: 6756-62 (2010) Article DOI: 10.1016/j.bmc.2010.07.051 BindingDB Entry DOI: 10.7270/Q2ZP472H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AICAR transformylase (Homo sapiens (Human)) | BDBM22579 (AICAR | Aminoimidazole-4-carboxamide ribonucleotid...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Pennsylvania State University Curated by ChEMBL | Assay Description Inhibitory activity against AICAR formyltransferase | J Med Chem 42: 3421-4 (1999) Article DOI: 10.1021/jm990323+ BindingDB Entry DOI: 10.7270/Q23X879T | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |