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BDBM226346 US9328096, 39

SMILES: Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cn[nH]c1

InChI Key: InChIKey=QIYIEMTXZQYTET-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226346   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM226346
PNG
(US9328096, 39)
Show SMILES Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cn[nH]c1
Show InChI InChI=1S/C26H18ClF2N7O2/c27-19-10-21(29)18(24-20(28)7-4-8-30-24)9-17(19)25(37)34-23-11-22(26(38)31-12-15-13-32-33-14-15)35-36(23)16-5-2-1-3-6-16/h1-11,13-14H,12H2,(H,31,38)(H,32,33)(H,34,37)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.94n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...


US Patent US9328096 (2016)


BindingDB Entry DOI: 10.7270/Q2FN152J
More data for this
Ligand-Target Pair