BDBM226366 US9328096, 59

SMILES: OCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1

InChI Key: InChIKey=VIKITGKRDZGGGR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 226366   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM226366 (US9328096, 59) Show SMILES OCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 Show InChI InChI=1S/C24H19Cl2N5O3/c25-18-13-19(26)17(12-16(18)20-8-4-5-9-27-20)23(33)29-22-14-21(24(34)28-10-11-32)30-31(22)15-6-2-1-3-7-15/h1-9,12-14,32H,10-11H2,(H,28,34)(H,29,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...				J Med Chem 62: 247-265 (2019) Article DOI: 10.1021/acs.jmedchem.8b00280
					More data for this Ligand-Target Pair
Tyrosine kinase receptor A (TrkA) (Homo sapiens (Human))	BDBM226366 (US9328096, 59) Show SMILES OCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 Show InChI InChI=1S/C24H19Cl2N5O3/c25-18-13-19(26)17(12-16(18)20-8-4-5-9-27-20)23(33)29-22-14-21(24(34)28-10-11-32)30-31(22)15-6-2-1-3-7-15/h1-9,12-14,32H,10-11H2,(H,28,34)(H,29,33)	PDB GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	14.6	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...				US Patent US9328096 (2016) BindingDB Entry DOI: 10.7270/Q2FN152J
					More data for this Ligand-Target Pair