BDBM226521 US9328096, 214

SMILES: Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cnn[nH]1

InChI Key: InChIKey=MCWNPNZAIBSNTR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226521   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine kinase receptor A (TrkA) (Homo sapiens (Human))	BDBM226521 (US9328096, 214) Show SMILES Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cnn[nH]1 Show InChI InChI=1S/C25H17ClF2N8O2/c26-18-10-20(28)17(23-19(27)7-4-8-29-23)9-16(18)24(37)32-22-11-21(25(38)30-12-14-13-31-35-33-14)34-36(22)15-5-2-1-3-6-15/h1-11,13H,12H2,(H,30,38)(H,32,37)(H,31,33,35)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.63	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...				US Patent US9328096 (2016) BindingDB Entry DOI: 10.7270/Q2FN152J
					More data for this Ligand-Target Pair