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BDBM226999 US9328096, 687

SMILES: Oc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)nc1

InChI Key: InChIKey=SWILKFWGVKOEON-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226999   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM226999
PNG
(US9328096, 687)
Show SMILES Oc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)nc1
Show InChI InChI=1S/C28H20ClFN6O3/c29-22-13-23(30)21(24-8-4-5-11-31-24)12-20(22)27(38)34-26-14-25(35-36(26)18-6-2-1-3-7-18)28(39)33-15-17-9-10-19(37)16-32-17/h1-14,16,37H,15H2,(H,33,39)(H,34,38)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.27n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...


US Patent US9328096 (2016)


BindingDB Entry DOI: 10.7270/Q2FN152J
More data for this
Ligand-Target Pair