BDBM227370 US9328106, 321

SMILES: Cn1ncc(NC(=O)c2csc(n2)-c2c(F)cccc2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1

InChI Key: InChIKey=PIBVQGPNQNIACT-IOASZLSFSA-N

Data: 1 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 227370   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227370 (US9328106, 321) Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2c(F)cccc2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r| Show InChI InChI=1S/C20H20F3N5O2S/c1-28-18(16-6-5-13(24)12(23)8-30-16)14(7-25-28)26-19(29)15-9-31-20(27-15)17-10(21)3-2-4-11(17)22/h2-4,7,9,12-13,16H,5-6,8,24H2,1H3,(H,26,29)/t12-,13-,16+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0137	-14.8	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
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