BDBM227407 US9328106, 359

SMILES: Cn1ncc(NC(=O)c2ccc(F)c(n2)-c2ccc(Cl)cc2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1

InChI Key: InChIKey=CEPMAZUDOYFZFJ-MDZRGWNJSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 227407   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227407 (US9328106, 359) Show SMILES Cn1ncc(NC(=O)c2ccc(F)c(n2)-c2ccc(Cl)cc2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 |r| Show InChI InChI=1S/C22H21ClF3N5O2/c1-31-21(19-7-5-16(27)15(26)10-33-19)18(9-28-31)30-22(32)17-6-4-13(24)20(29-17)12-3-2-11(23)8-14(12)25/h2-4,6,8-9,15-16,19H,5,7,10,27H2,1H3,(H,30,32)/t15-,16-,19+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.00700	-15.2	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
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