BDBM227552 US9339486, CP55,940
SMILES: CCCCCCC(C)(C)c1ccc(C2CC(O)CCC2CCCO)c(O)c1
InChI Key: InChIKey=YNZFFALZMRAPHQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM227552 (US9339486, CP55,940) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | US Patent | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Cell membrane homogenates (15 μg protein) were incubated for 120 min at 37° C. with 0.8 nM [3H]WIN 55212-2 (the reference standard [Munro, 1993 ... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM227552 (US9339486, CP55,940) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Cell membrane homogenates (25 μg protein) were incubated for 120 min at 37° C. with 0.5 nM [3H]CP 55940 (the reference standard [Rinaldi-Carmona... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM227552 (US9339486, CP55,940) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM227552 (US9339486, CP55,940) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | US Patent | n/a | n/a | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Rattus norvegicus (Rat)) | BDBM227552 (US9339486, CP55,940) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | US Patent | n/a | n/a | n/a | n/a | 1.13 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description The compound of Example 3 was tested for agonist activity at the rat CB1 (rCB1) and rCB2 receptors, at eight concentrations, in duplicate: 10, 3, 1, ... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM227552 (US9339486, CP55,940) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
The Cleveland Clinic Foundation US Patent | Assay Description Functional activity was evaluated using GTPγ[35S] assay in CHO membrane extracts expressing recombinant hCB1 (human CB1) receptors or hCB2 (huma... | US Patent US9339486 (2016) BindingDB Entry DOI: 10.7270/Q2DN43W9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |