BDBM227633 MTH1 inhibitor, 120

SMILES: C(Nc1ncnc2[nH]cnc12)c1ccc2OCOc2c1

InChI Key: InChIKey=YRSAPERCOVONIV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 227633   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MutT homolog 1 protein (MTH1) (Homo sapiens (Human))	BDBM227633 (MTH1 inhibitor, 120) Show SMILES C(Nc1ncnc2[nH]cnc12)c1ccc2OCOc2c1 Show InChI InChI=1S/C13H11N5O2/c1-2-9-10(20-7-19-9)3-8(1)4-14-12-11-13(16-5-15-11)18-6-17-12/h1-3,5-6H,4,7H2,(H2,14,15,16,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	7.5	n/a
RIKEN Center for Life Science Technologies					Assay Description Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...				Chem Biol Drug Des 89: 862-869 (2017) Article DOI: 10.1111/cbdd.12909 BindingDB Entry DOI: 10.7270/Q24748RZ
					More data for this Ligand-Target Pair
MutT homolog 1 protein (MTH1) (Homo sapiens (Human))	BDBM227633 (MTH1 inhibitor, 120) Show SMILES C(Nc1ncnc2[nH]cnc12)c1ccc2OCOc2c1 Show InChI InChI=1S/C13H11N5O2/c1-2-9-10(20-7-19-9)3-8(1)4-14-12-11-13(16-5-15-11)18-6-17-12/h1-3,5-6H,4,7H2,(H2,14,15,16,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	7.5	n/a
RIKEN Center for Life Science Technologies					Assay Description Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...				Chem Biol Drug Des 89: 862-869 (2017) Article DOI: 10.1111/cbdd.12909 BindingDB Entry DOI: 10.7270/Q24748RZ
					More data for this Ligand-Target Pair