BDBM227728 3-(4-fluorophenyl)-n-(6-methoxy-1h-indazol-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine::US9556181, 13

SMILES: COc1cc2[nH]ncc2cc1Nc1ncnc2[nH]nc(-c3ccc(F)cc3)c12

InChI Key: InChIKey=QNYYTTMBBCPPCL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 227728   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase signal-integrating kinase 1 (MKNK1) (Homo sapiens (Human))	BDBM227728 (3-(4-fluorophenyl)-n-(6-methoxy-1h-indazol-5-yl)-1...) Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2[nH]nc(-c3ccc(F)cc3)c12 Show InChI InChI=1S/C19H14FN7O/c1-28-15-7-13-11(8-23-25-13)6-14(15)24-18-16-17(10-2-4-12(20)5-3-10)26-27-19(16)22-9-21-18/h2-9H,1H3,(H,23,25)(H2,21,22,24,26,27)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description TBDA recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accessio...				US Patent US9556181 (2017) BindingDB Entry DOI: 10.7270/Q2C53NTH
					More data for this Ligand-Target Pair