BDBM229679 US9334269, 6

SMILES: CNC(=O)c1cc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(cc2)C(F)(F)F)ccc1F

InChI Key: InChIKey=XTAYGNQXKUWVPX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 229679   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM229679 (US9334269, 6) Show SMILES CNC(=O)c1cc(Nc2ncnc(n2)N2CC(C2)Oc2ccc(cc2)C(F)(F)F)ccc1F Show InChI InChI=1S/C21H18F4N6O2/c1-26-18(32)16-8-13(4-7-17(16)22)29-19-27-11-28-20(30-19)31-9-15(10-31)33-14-5-2-12(3-6-14)21(23,24)25/h2-8,11,15H,9-10H2,1H3,(H,26,32)(H,27,28,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...				US Patent US9334269 (2016) BindingDB Entry DOI: 10.7270/Q2M32TNF
					More data for this Ligand-Target Pair